Abstract We analyze annually resolved tree-ring stable carbon (δ13C) and oxygen (δ18O) isotopic chronologies from Swiss stone pine (Pinus cembra L.) in Romania. The chronologies cover the period between 1876 and 2012 and integrate data from four individual trees from the Calimani Mts in the eastern Carpathians where climatic records are scarce and starts only from 1961. Calibration trials show that the δ13C values correlate with local April-May relative humidity and with regional to larger scale (European) summer precipitation. δ18O correlates significantly with local relative humidity, cloud cover, maximum temperature, as well as European scale drought conditions. In all cases, the climate effects on δ13C values are weaker than those recorded in the δ18O data, with the latter revealing a tendency towards higher (lower) values of δ18O during extremely dry (wet) years. The most striking signal, however, is the strong link between the interannual δ18O variability recorded in the Calimani Mts and large-scale circulation patterns associated with North Atlantic and Mediteraneean Sea sea surface temperatures. High (low) values of δ18O occur in association with a high (low) pressure system over the central and eastern part of Europe and with a significantly warmer (colder) Mediterranean Sea surface temperature. These results demonstrate the possibility of using tree ring oxygen isotopes from the eastern Carpathians to reconstruct regional drought conditions in eastern Europe on long-term time scales and larger scale circulation dynamics over the pre-instrumental periods.